The role of the MDR 1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo
Identifieur interne : 002E52 ( Main/Exploration ); précédent : 002E51; suivant : 002E53The role of the MDR 1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo
Auteurs : Igor B. Roninson [États-Unis]Source :
- Biochemical Pharmacology [ 0006-2952 ] ; 1992.
English descriptors
- KwdEn :
- PCR.
- Teeft :
- Acad, Assay, Biol, Biol chem, Bone marrow, Carcinoma, Carcinoma cells, Cdna, Cell biol, Cell line, Cell lines, Cellular biology, Chemotherapy, Clinical cancer, Coding sequence, Colchicine, Cytotoxic, Cytotoxic selection, Different drugs, Different types, Drug selection, Efflux, Functional role, Gene, Gene family, Gottesman, Gros, Hematopoietic, Hematopoietic progenitor cells, High levels, Highest levels, Human cells, Immunohistochemical, Infectants, Mdr1, Mdr1 expression, Mdr1 gene, Mdr2, Mdrl, Mdrl gene, Multidrug, Multidrug resistance, Multidrug resistance gene, Multidrug resistance gene product, Mutant, Mutant protein, Mutation, Natl, Natl cancer inst, Neoplastic transformation, Normal tissues, Pastan, Pglycoprotein, Pglycoprotein inhibitors, Phenotype, Plenum, Plenum press, Point mutations, Preferential resistance, Proc, Proc natl acad, Roninson, Selective agent, Subpopulation, Tumor cells, Unpublished data, Untreated, Untreated tumors.
Abstract
Abstract: This review describes the studies that address the role of the MDR1 (P-glycoprotein) gene in multidrug resistance in cell lines selected in vitro and in clinical cancer. Molecular genetic studies have demonstrated that expression of P-glycoprotein, an efflux pump acting at diverse lipophilic compounds, is sufficient to provide resistance to a large number of lipophilic drugs in tissue culture. The MDR1 gene is expressed in several normal human tissues associated with secretory or barrier functions and in some bone marrow and blood cells, including hematopoietic progenitor cells. MDR1 expression in clinical cancer is often found in untreated tumors of different types. Several studies showed a correlation between MDR1 expression and tumor resistance to combination chemotherapy. MDR1 expression in untreated tumors may reflect their origin from MDR1-positive normal cells or cellular changes associated with neoplastic transformation or progression. MDR1 expression in some types of cancer may be a marker of a more aggressive subpopulation of tumor cells, possessing multiple mechanisms for resistance to treatment.
Url:
DOI: 10.1016/0006-2952(92)90666-7
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002B11
- to stream Istex, to step Curation: 002B11
- to stream Istex, to step Checkpoint: 001C25
- to stream Main, to step Merge: 002F18
- to stream Main, to step Curation: 002E52
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The role of the MDR 1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo</title><author><name sortKey="Roninson, Igor B" sort="Roninson, Igor B" uniqKey="Roninson I" first="Igor B." last="Roninson">Igor B. Roninson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C88202C506ADF37D4FCF254C518211F34549042E</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0006-2952(92)90666-7</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-2VPBGDFN-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002B11</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002B11</idno><idno type="wicri:Area/Istex/Curation">002B11</idno><idno type="wicri:Area/Istex/Checkpoint">001C25</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001C25</idno><idno type="wicri:doubleKey">0006-2952:1992:Roninson I:the:role:of</idno><idno type="wicri:Area/Main/Merge">002F18</idno><idno type="wicri:Area/Main/Curation">002E52</idno><idno type="wicri:Area/Main/Exploration">002E52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The role of the MDR 1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo</title><author><name sortKey="Roninson, Igor B" sort="Roninson, Igor B" uniqKey="Roninson I" first="Igor B." last="Roninson">Igor B. Roninson</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, University of Illinois at Chicago, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Biochemical Pharmacology</title><title level="j" type="abbrev">BCP</title><idno type="ISSN">0006-2952</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">43</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="95">95</biblScope><biblScope unit="page" to="102">102</biblScope></imprint><idno type="ISSN">0006-2952</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-2952</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PCR</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acad</term><term>Assay</term><term>Biol</term><term>Biol chem</term><term>Bone marrow</term><term>Carcinoma</term><term>Carcinoma cells</term><term>Cdna</term><term>Cell biol</term><term>Cell line</term><term>Cell lines</term><term>Cellular biology</term><term>Chemotherapy</term><term>Clinical cancer</term><term>Coding sequence</term><term>Colchicine</term><term>Cytotoxic</term><term>Cytotoxic selection</term><term>Different drugs</term><term>Different types</term><term>Drug selection</term><term>Efflux</term><term>Functional role</term><term>Gene</term><term>Gene family</term><term>Gottesman</term><term>Gros</term><term>Hematopoietic</term><term>Hematopoietic progenitor cells</term><term>High levels</term><term>Highest levels</term><term>Human cells</term><term>Immunohistochemical</term><term>Infectants</term><term>Mdr1</term><term>Mdr1 expression</term><term>Mdr1 gene</term><term>Mdr2</term><term>Mdrl</term><term>Mdrl gene</term><term>Multidrug</term><term>Multidrug resistance</term><term>Multidrug resistance gene</term><term>Multidrug resistance gene product</term><term>Mutant</term><term>Mutant protein</term><term>Mutation</term><term>Natl</term><term>Natl cancer inst</term><term>Neoplastic transformation</term><term>Normal tissues</term><term>Pastan</term><term>Pglycoprotein</term><term>Pglycoprotein inhibitors</term><term>Phenotype</term><term>Plenum</term><term>Plenum press</term><term>Point mutations</term><term>Preferential resistance</term><term>Proc</term><term>Proc natl acad</term><term>Roninson</term><term>Selective agent</term><term>Subpopulation</term><term>Tumor cells</term><term>Unpublished data</term><term>Untreated</term><term>Untreated tumors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This review describes the studies that address the role of the MDR1 (P-glycoprotein) gene in multidrug resistance in cell lines selected in vitro and in clinical cancer. Molecular genetic studies have demonstrated that expression of P-glycoprotein, an efflux pump acting at diverse lipophilic compounds, is sufficient to provide resistance to a large number of lipophilic drugs in tissue culture. The MDR1 gene is expressed in several normal human tissues associated with secretory or barrier functions and in some bone marrow and blood cells, including hematopoietic progenitor cells. MDR1 expression in clinical cancer is often found in untreated tumors of different types. Several studies showed a correlation between MDR1 expression and tumor resistance to combination chemotherapy. MDR1 expression in untreated tumors may reflect their origin from MDR1-positive normal cells or cellular changes associated with neoplastic transformation or progression. MDR1 expression in some types of cancer may be a marker of a more aggressive subpopulation of tumor cells, possessing multiple mechanisms for resistance to treatment.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de l'Illinois à Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Roninson, Igor B" sort="Roninson, Igor B" uniqKey="Roninson I" first="Igor B." last="Roninson">Igor B. Roninson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002E52 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002E52 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:C88202C506ADF37D4FCF254C518211F34549042E
|texte= The role of the MDR 1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo
}}
| This area was generated with Dilib version V0.6.33. |  |